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[020] The disclosure provides an isolated antibody or antigen-binding fragment thereof, comprising a heavy chain and a light chain, wherein the heavy chain comprises a heavy chain frame work region sequence of a Germline family of an anti-CLEC2D antibody selected from the group consisting of: Al, Bl, El, PI, Ul, Yl, E2, 12 and L2, of Table 9B, as disclosed herein, and wherein the light chain comprises a frame work region sequence of a light chain Germline family of an anti-CLEC2D antibody selected from the group consisting of: Al, Bl, El, PI, Ul, Yl, E2, 12 and L2, of Table 9B, as disclosed herein